•Identified in 1979
•The TP53 gene from the mouse was first cloned in 1982.
•The human TP53 gene was cloned in 1984 and the full length clone in 1985.
•In 1991-92 reported that TP53 was a critical part of a signal transduction pathway that helped cells respond to DNA damage.
•in1992THE GUARDIAN OF THE GENOME” by Nature magazine.
•In 1993, p53 was voted molecule of the year by Science magazine.
•In 1993 discovered p21(WAF1) as a gene regulated directly by p53.
•Presently, p53 is known to play a key role in practically all types of human cancers, and the mutation or loss of the p53 gene can be identified in more than 50% of all human cancer cases worldwide.
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